Jun-Jie (Gogo) Liu
PI
Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University
junjiegogoliu(at)tsinghua.edu.cn
Please replace (at) with @ for contact
Current Members
Pujuan Deng
Postdoc
Email: dengpj(at)mail.tsinghua.edu.cn
Research Topic:
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
Shouyue Zhang
Postdoc
Email: shouyuezhang(at)mail.tsinghua.edu.cn
Research Topic:
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
![mmexport1605609323137[1].jpg](https://static.wixstatic.com/media/105bd6_7cb6021337b847e7ab5fe2128ef44d36~mv2.jpg/v1/fill/w_240,h_320,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609323137%5B1%5D.jpg)
Danyuan Li
Ph. D. Student
Email: li-dy18(at)mails.tsinghua.edu.cn
Research Topic:
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
Yun Yang
Ph. D. Student
Email: yangyun19(at)mails.tsinghua.edu.cn
Research Topic:
My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.
Hanzhou Zhu
Ph. D. Student
Email: zhz20(at)mails.tsinghua.edu.cn
Research Topic:
I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.
Chengping Li
Ph. D. Student
Email: lcp20(at)mails.tsinghua.edu.cn
Research Topic:
Excavating novel CRISPR-Cas and other systems with the potential of genome editings, such as prokaryotic Argonautes and ribozymes, by bioinformatic methods. Structural determination of proteins and RNAs using Cryo-EM and related data analysis tools.
Ao Sun
Ph. D. Student
Email: sunao20(at)mails.tsinghua.edu.cn
Research Topic:
1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools
![mmexport1605609348461[1].jpg](https://static.wixstatic.com/media/105bd6_07221a6d898548b6911c5e7fe70fc4b5~mv2.jpg/v1/crop/x_0,y_68,w_668,h_833/fill/w_248,h_309,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609348461%5B1%5D.jpg)
Zixian Liu
Ph. D. Student
Email: liuzx21(at)mails.tsinghua.edu.cn
Research Topic:
My reaserch focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.
Shunqing Tan
Ph. D. Student
Email: tansq21(at)ucl.ac.uk
Research Topic:
Exploring the mechanism of nuclease activities and developing novel gene editing tools.
Postdocs and Ph.D. Candidates...
Alumni
Dandan Sun
2020.4-2021.7, Lab Manager
Current, Laboratory engineer
![mmexport1605609293265[1].jpg](https://static.wixstatic.com/media/105bd6_4e6a71bbf7c94e56928c53a67238aacf~mv2.jpg/v1/fill/w_113,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609293265%5B1%5D.jpg)
Xinyi Wu
2020.10-2021.4, Visiting Student
Current, JiMei University
![mmexport1605609264211[1].jpg](https://static.wixstatic.com/media/105bd6_6d67cfb2c1764cac8baba787c8ed61fd~mv2.jpg/v1/crop/x_415,y_357,w_451,h_544/fill/w_124,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609264211%5B1%5D.jpg)
Zhuoyan Hai
2020.10-2021.8, Visiting Student
Current, Ph.D. in Tsinghua University
Jiahui Zhao
2020.10-2021.8, Visiting Scholar
Current, master student
in Columbia University
2021.5-2021.11, Visiting Scholar
Tingxuan Yang
Yuqian Zhao
2020.5-2022.6, Postdoc
Zhihao Jing
2021.9-2022.7, Visiting Scholar
Current, Tibet Agricultural and Animal Husbandry University
Qiaoyang Ma
2021.9-2022.8, Visiting Student
Current, Ph.D. in Tsinghua University
Yutao Chen
2021.10-2022.7, Visiting Student
Current, Ph.D. in Tsinghua University
Longqi Li
2021.10-2022.8, Visiting Student
Current, Ph.D. in Tsinghua University
Min Li
Lab Manager
Email: mmli(at)mail.tsinghua.edu.cn
Zhihang Chen
Postdoc
Email: zhihangchen(at)mail.tsinghua.edu.cn
Research Topic:
Directed evolution of novel nucleic acid manipulation systems for precise & high efficiency gene editing.
