Jun-Jie (Gogo) Liu
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Please replace (at) with @ for contact
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
My research goal is to improve gene editing efficiency of CasX in mammal cells and engineer CasX to other powerful gene editing technologies, such as base editor.
I am interested in developing novel genome-editing tools beyond CRISPR-Cas systems. My current research is focused on increasing the editing efficiency of DNA-guided prokaryotic Argonautes in mammalian cells, which will greatly broaden their biotechnological applications.
Ph. D. Student
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
To explore the potential of new nucleic acid manipulation tools, I hope to be able to find gene specific insertion methods that are more efficient than the CRISPR system. Currently, R2 reverse transcriptase is being studied in the hope of successfully extracting the target protein and studying its molecular mechanism.
I am interested in exploiting novel CRISPR system including bioinformation mining and its biochemical mechanisms, as well as the evolutionary relationship and biological significance between gRNA and CAS protein family.
My work now is primarily focusing on the molecular mechanism of ribozymes.