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Jun-Jie (Gogo) Liu

PI

Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

Please replace (at) with @ for contact

Current Members

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Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic: 

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

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Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

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Danyuan Li

Ph. D. Student

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

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​Hanzhou Zhu

Ph. D. Student

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism. 
II) Developing a new method for RNA purification from in vivo system. 
III) RNA degradation by the exosome.

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Chengping Li

Ph. D. Student

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Excavating new CRISPR-Cas and other systems with the potential of genome editing, such as prokaryotic Argonautes and ribozymes, by bioinformatic methods. Structural determination of proteins and RNAs using Cryo-EM and related data analysis tools.

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Ao Sun

Ph. D. Student

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

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Jiahui Zhao

Visiting Scholar 

Email: zzzjjhhh(at)gmail.com

Research Topic:

I am interested in developing novel genome-editing tools beyond CRISPR-Cas systems. Replacement of RNA guides with DNA guides will greatly reduce the cost of in vivo gene editing, especially for high-throughput screening. My current research is focused on the engineering of prokaryotic Argonaute, a group of  DNA-guided endonucleases, to edit the genome of mammalian cells.

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Tingxuan Yang

Visiting Scholar 

Email: wayneyoung1997(at)126.com

Research Topic:

Understanding the gene insertion mechanism and gene editing capacity of retrospective elements via DNA, RNA, and protein complex structural analysis by cryo-electron microscope to exploit new gene-editing tools.

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Zhuoyan Hai

Visiting Scholar 

Email: haizy-bnu(at)mail.bnu.edu.cn

Research Topic:

I am interested in exploiting novel CRISPR system including bioinformation mining and its biochemical mechanisms, as well as the evolutionary relationship and biological significance between gRNA and CAS protein family.

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Zixian Liu

Visiting Scholar 

Email: 2017301040189(at)whu.edu.cn

Research Topic:

My work now is primarily focusing on the molecular mechanism of ribozymes.

Black Sheep

...

PhD Candidate

Alumni

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Dandan Sun

​Lab Manager

Email: dandansun(at)mail.tsinghua.edu.cn

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Min Li

​Lab Manager

Email: limm0620(at)126.com

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Yuqian Zhao

Postdoc

Email: zyq031(at)mail.tsinghua.edu.cn

Research Topic:

My research goal is to improve gene editing efficiency of CasX in mammal cells and engineer CasX to other powerful gene editing technologies, such as base editor. 

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