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Jun-Jie (Gogo) Liu

PI

Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

Please replace (at) with @ for contact

Current Members

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Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic: 

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

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Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

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Danyuan Li

Ph. D. Student

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

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Yun Yang​

Ph. D. Student

Email: yangyun19(at)mails.tsinghua.edu.cn

Research Topic:

My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.

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​Hanzhou Zhu

Ph. D. Student

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism. 
II) Developing a new method for RNA purification from in vivo system. 
III) RNA degradation by the exosome.

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Chengping Li

Ph. D. Student

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Excavating novel CRISPR-Cas and other systems with the potential of genome editings, such as prokaryotic Argonautes and ribozymes, by bioinformatic methods. Structural determination of proteins and RNAs using Cryo-EM and related data analysis tools.

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Ao Sun

Ph. D. Student

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

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Zixian Liu

Ph. D. Student

Email: liuzx21(at)mails.tsinghua.edu.cn

Research Topic:

My reaserch focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.

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Shunqing Tan

Ph. D. Student

Email: tansq21(at)ucl.ac.uk

Research Topic:

Exploring the mechanism of nuclease activities and developing novel gene editing tools.

Black Sheep

Postdocs and Ph.D. Candidates...

Alumni

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Dandan Sun

2020.4-2021.7, Lab Manager

​Current, Laboratory engineer​

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Xinyi Wu

2020.10-2021.4, Visiting Student

​Current, JiMei University​

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Zhuoyan Hai

2020.10-2021.8, Visiting Student

​Current, Ph.D. in Tsinghua University​

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Jiahui Zhao

2020.10-2021.8, Visiting Scholar 

​Current, master student 

                 in Columbia University​

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2021.5-2021.11, Visiting Scholar

Tingxuan Yang

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Yuqian Zhao

2020.5-2022.6, Postdoc

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Zhihao Jing

2021.9-2022.7, Visiting Scholar

Current, Tibet Agricultural and Animal Husbandry University

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Qiaoyang Ma

2021.9-2022.8, Visiting Student

Current, Ph.D. in Tsinghua University​

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Yutao Chen

2021.10-2022.7, Visiting Student

Current, Ph.D. in Tsinghua University​

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Longqi Li

2021.10-2022.8, Visiting Student

Current, Ph.D. in Tsinghua University​

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Min Li

​Lab Manager

Email: mmli(at)mail.tsinghua.edu.cn

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Zhihang Chen

Postdoc

Email: zhihangchen(at)mail.tsinghua.edu.cn

Research Topic:

Directed evolution of novel nucleic acid manipulation systems for precise & high efficiency gene editing.

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