Jun-Jie (Gogo) Liu
PI
Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University
junjiegogoliu(at)tsinghua.edu.cn
Please replace (at) with @ for contact
Current Members
Pujuan Deng
Postdoc
Email: dengpj(at)mail.tsinghua.edu.cn
Research Topic:
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
Shouyue Zhang
Postdoc
Email: shouyuezhang(at)mail.tsinghua.edu.cn
Research Topic:
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
![mmexport1605609323137[1].jpg](https://static.wixstatic.com/media/105bd6_7cb6021337b847e7ab5fe2128ef44d36~mv2.jpg/v1/fill/w_240,h_320,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609323137%5B1%5D.jpg)
Danyuan Li
Ph. D. Student
Email: li-dy18(at)mails.tsinghua.edu.cn
Research Topic:
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
Hanzhou Zhu
Ph. D. Student
Email: zhz20(at)mails.tsinghua.edu.cn
Research Topic:
I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.
Chengping Li
Ph. D. Student
Email: lcp20(at)mails.tsinghua.edu.cn
Research Topic:
Excavating novel CRISPR-Cas and other systems with the potential of genome editings, such as prokaryotic Argonautes and ribozymes, by bioinformatic methods. Structural determination of proteins and RNAs using Cryo-EM and related data analysis tools.
Ao Sun
Ph. D. Student
Email: sunao20(at)mails.tsinghua.edu.cn
Research Topic:
1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools
![mmexport1605609348461[1].jpg](https://static.wixstatic.com/media/105bd6_07221a6d898548b6911c5e7fe70fc4b5~mv2.jpg/v1/crop/x_0,y_68,w_668,h_833/fill/w_248,h_309,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609348461%5B1%5D.jpg)
Zixian Liu
Ph. D. Student
Email: liuzx21(at)mails.tsinghua.edu.cn
Research Topic:
My reaserch focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.
Longqi Li
Undergraduate Student
Email: 13467027728llqcqlxd(at)sjtu.edu.cn
Research Topic:
Exploiting prokaryotic Ago proteins as novel DNA-guided gene-editing tools.
Qiaoyang Ma
Undergraduate Student
Email: zcbtqma(at)ucl.ac.uk
Research Topic:
Investigation of long non-coding RNA structures and its relevant RNA-protein structures by using Cryo-EM so as to characterize the function of certain lncRNAs.
Yutao Chen
Undergraduate Student
Email: chenyt258(at)mail2.sysu.edu.cn
Research Topic:
Development and improvement of novel nucleic acid manipulation tools based on different biomolecules.
Zhihao Jing
Visiting Scholar
Email: zkxyjzh(at)xza.edu.cn
Research Topic:
research topic: Optimizing the existing micro CasX nuclease and delivery system, improving the gene editing efficiency of CasX.
Postdocs and Ph.D. Candidates...
Alumni
Dandan Sun
2020.4-2021.7, Lab Manager
Current, Laboratory engineer
![mmexport1605609293265[1].jpg](https://static.wixstatic.com/media/105bd6_4e6a71bbf7c94e56928c53a67238aacf~mv2.jpg/v1/fill/w_113,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609293265%5B1%5D.jpg)
Xinyi Wu
2020.10-2021.4, Visiting Student
Current, JiMei University
![mmexport1605609264211[1].jpg](https://static.wixstatic.com/media/105bd6_6d67cfb2c1764cac8baba787c8ed61fd~mv2.jpg/v1/crop/x_415,y_357,w_451,h_544/fill/w_124,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609264211%5B1%5D.jpg)
Zhuoyan Hai
2020.10-2021.8, Visiting Student
Current, Ph.D. in Tsinghua University
Jiahui Zhao
2020.10-2021.8, Visiting Scholar
Current, master student
in Columbia University
2021.5-2021.11, Visiting Scholar
Tingxuan Yang
Min Li
Lab Manager
Email: mmli(at)mail.tsinghua.edu.cn
Yuqian Zhao
Postdoc
Email: zyq031(at)mail.tsinghua.edu.cn
Research Topic:
My research goal is to improve gene editing efficiency of CasX in mammal cells and engineer CasX to other powerful gene editing technologies, such as base editor.
