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Jun-Jie (Gogo) Liu

PI

Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

Please replace (at) with @ for contact

Current Members

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Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic: 

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

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Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

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Danyuan Li

Ph. D. Student

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

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​Hanzhou Zhu

Ph. D. Student

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism. 
II) Developing a new method for RNA purification from in vivo system. 
III) RNA degradation by the exosome.

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Chengping Li

Ph. D. Student

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Excavating novel CRISPR-Cas and other systems with the potential of genome editings, such as prokaryotic Argonautes and ribozymes, by bioinformatic methods. Structural determination of proteins and RNAs using Cryo-EM and related data analysis tools.

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Ao Sun

Ph. D. Student

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

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Zixian Liu

Ph. D. Student

Email: liuzx21(at)mails.tsinghua.edu.cn

Research Topic:

My reaserch focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.

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Longqi Li

Undergraduate Student

Email: 13467027728llqcqlxd(at)sjtu.edu.cn

Research Topic:

Exploiting prokaryotic Ago proteins as novel DNA-guided gene-editing tools.

 

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Qiaoyang Ma

Undergraduate Student

Email: zcbtqma(at)ucl.ac.uk

Research Topic:

Investigation of long non-coding RNA structures and its relevant RNA-protein structures by using Cryo-EM so as to characterize the function of certain lncRNAs. 

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Yutao Chen

Undergraduate Student

Email: chenyt258(at)mail2.sysu.edu.cn

Research Topic:

Development and improvement of novel nucleic acid manipulation tools based on different biomolecules.

 

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Zhihao Jing

Visiting Scholar 

Email: zkxyjzh(at)xza.edu.cn

Research Topic:

research topic: Optimizing the existing micro CasX nuclease and delivery system, improving the gene editing efficiency of CasX.

Black Sheep

Postdocs and Ph.D. Candidates...

Alumni

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Dandan Sun

2020.4-2021.7, Lab Manager

​Current, Laboratory engineer​

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Xinyi Wu

2020.10-2021.4, Visiting Student

​Current, JiMei University​

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Zhuoyan Hai

2020.10-2021.8, Visiting Student

​Current, Ph.D. in Tsinghua University​

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Jiahui Zhao

2020.10-2021.8, Visiting Scholar 

​Current, master student 

                 in Columbia University​

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2021.5-2021.11, Visiting Scholar

Tingxuan Yang

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Min Li

​Lab Manager

Email: mmli(at)mail.tsinghua.edu.cn

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Yuqian Zhao

Postdoc

Email: zyq031(at)mail.tsinghua.edu.cn

Research Topic:

My research goal is to improve gene editing efficiency of CasX in mammal cells and engineer CasX to other powerful gene editing technologies, such as base editor. 

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