Jun-Jie (Gogo) Liu

Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

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Current Members

Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic:

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

Shuai Jin

Postdoc

Email: shuaijin(at)mail.tsinghua.edu.cn

Research Topic:

I) Directed evolution of the entire human or plant genomes.
II) Specificity of precise genome editing systems.
III) Evolutionary trajectory of CRISPR systems.

Yuanyuan Jiang

Postdoc

Email: jiangyyuan(at)mail.tsinghua.edu.cn

Research Topic:

(1) Exploring the mechanisms and biological functions of ribozymes;

(2) Developing novel RNA-based nucleic acid manipulation tools within animal and plant organisms.

Danyuan Li

Ph. D. Candidate

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

Yun Yang

Ph. D. Candidate

Email: yangyun19(at)mails.tsinghua.edu.cn

Research Topic:

My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.

Hanzhou Zhu

Ph. D. Candidate

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.

Chengping Li

Ph. D. Candidate

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.

Determining the 3D structures of proteins and RNAs using Cryo-EM.

Ao Sun

Ph. D. Candidate

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

Zixian Liu

Ph. D. Student

Email: liuzx21(at)mails.tsinghua.edu.cn

Research Topic:

My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.