Jun-Jie (Gogo) Liu
PI
Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University
junjiegogoliu(at)tsinghua.edu.cn
Please replace (at) with @ for contact
Current Members
Pujuan Deng
Postdoc
Email: dengpj(at)mail.tsinghua.edu.cn
Research Topic:
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
Shouyue Zhang
Postdoc
Email: shouyuezhang(at)mail.tsinghua.edu.cn
Research Topic:
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
Shuai Jin
Postdoc
Email: shuaijin(at)mail.tsinghua.edu.cn
Research Topic:
I) Directed evolution of the entire human or plant genomes.
II) Specificity of precise genome editing systems.
III) Evolutionary trajectory of CRISPR systems.
Yuanyuan Jiang
Postdoc
Email: jiangyyuan(at)mail.tsinghua.edu.cn
Research Topic:
(1) Exploring the mechanisms and biological functions of ribozymes;
(2) Developing novel RNA-based nucleic acid manipulation tools within animal and plant organisms.
Zheng Zhang
Postdoc
Email: zhengzhang61(at)mail.tsinghua.edu.cn
Research Topic:
Developing and optimizing RNA-based nucleic acid editing tools.
Editing is not manipulation but only guidance for the genome to fix itself.
Danyuan Li
Ph. D. Candidate
Email: li-dy18(at)mails.tsinghua.edu.cn
Research Topic:
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
Jingbo Jiang
Ph. D. Candidate - joint PhD. student
Email: jiangjb18(at)mails.tsinghua.edu.cn
Research Topic:
(1) Studying on physiological RNA substrate of RNA exosome complex in direct-access route by biochemistry and structure;
(2) Exploring new cofactors of RNA exosome complex in yeast and human cells and determining the complex structures.
Yun Yang
Ph. D. Candidate
Email: yangyun19(at)mails.tsinghua.edu.cn
Research Topic:
My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.
Mingzhe Xia
Ph. D. Candidate- joint PhD. student
Email: xmz19(at)mails.tsinghua.edu.cn
Research Topic:
(1) Study the mechanism of low phosphorus response and root hair development of Arabidopsis.
(2) Exploring the biochemical properties of plant transposase and their effects on biological functions.
Chengping Li
Ph. D. Candidate
Email: lcp20(at)mails.tsinghua.edu.cn
Research Topic:
Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.
Determining the 3D structures of proteins and RNAs using Cryo-EM.
Hanzhou Zhu
Ph. D. Candidate
Email: zhz20(at)mails.tsinghua.edu.cn
Research Topic:
I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.
Ao Sun
Ph. D. Candidate
Email: sunao20(at)mails.tsinghua.edu.cn
Research Topic:
1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools
Shunqing Tan
Ph. D. Candidate
Email: tansq21(at)mails.tsinghua.edu.cn
Research Topic:
Exploring the mechanism of nuclease activities and developing novel gene editing tools.
Zixian Liu
Ph. D. Candidate
Email: liuzx21(at)mails.tsinghua.edu.cn
Research Topic:
My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.
Longqi Li
Ph. D. Student
Email: lilq22(at)mails.tsinghua.edu.cn
Research Topic:
Detection of gene-editing potential of novel nucleases in mammalian cells and Development of the next-generation gene-manipulating toolbox.
Shuo Lin
Ph. D. Student
Email:lins23@mails.tsinghua.edu.cn
Research Topic:
Mining new ribozyme in matagenomic database and using structual biology approach to solve the mechenism
Gaoli Wang
Ph. D. Student
Email: wanggl23(at)mails.tsinghua.edu.cn
Research Topic:
Searching for ribozymes with novel functions and exploring their applications as biological tools
Shulin Jin
Ph. D. Student
Email: jsl23(at)mails.tsinghua.edu.cn
Research Topic:
Exploring the mechanism of novel RNA-involved nuclease system by using biochemistry methods.
Zhonghao Zhang
Research assitant
Email: zhonghaozhang2022(at)163.com
I graduated from Ocean University of China with a master's degree. I am currently working as a research assistant. I am easy-going, sincere, ready to help others, serious and responsible for work.
Postdocs and Ph.D. Candidates...
Alumni
Dandan Sun
2020.4-2021.7, Lab Manager
Current, Laboratory engineer
Xinyi Wu
2020.10-2021.4, Visiting Student
Current, JiMei University
Zhuoyan Hai
2020.10-2021.8, Visiting Student
Current, Ph.D. in Tsinghua University
Jiahui Zhao
2020.10-2021.8, Visiting Scholar
Current, master student
in Columbia University
2021.5-2021.11, Visiting Scholar
Tingxuan Yang
Yuqian Zhao
2020.5-2022.6, Postdoc
Zhihao Jing
2021.9-2022.7, Visiting Scholar
Current, Tibet Agricultural and Animal Husbandry University
Qiaoyang Ma
2021.9-2022.8, Visiting Student
Current, Ph.D. in Tsinghua University
Yutao Chen
2021.10-2022.7, Visiting Student
Current, Ph.D. in Tsinghua University
Zhihang Chen
2022.3-2024.3, Postdoc
Current,the Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Science
SweeHong Ng
2023.9-2024.4, Visiting Student
Current, in Tsinghua University
Min Li
Lab Manager
Email: mmli(at)mail.tsinghua.edu.cn
Undergraduate Students
Zhaofu Li
Tsinghua University
Grade 2021
Qiyu Yang
Tsinghua University
Grade 2021
Yun Liu
Tsinghua University
Grade 2021
Xiaozheng Yang
Tsinghua University
Grade 2020
Tsinghua University
Grade 2023
Runheng Zhang
Matylda Zuzanna Klos
University of Manchester
Grade 2021
Jiantao Zhang
Tsinghua University
Grade 2023
Yue Zhang
Nanjing Agricultural University
Grade 2020
Yuntian Yang
Lanzhou University
Grade 2020
Wenwen Wang
Sun Yat-sen University
Grade 2019
Yang Yi
Sichuan University
Grade 2020