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Jun-Jie (Gogo) Liu

PI

Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

Please replace (at) with @ for contact

Current Members

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Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic: 

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

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Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

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Shuai Jin

Postdoc

Email: shuaijin(at)mail.tsinghua.edu.cn

Research Topic:

I) Directed evolution of the entire human or plant genomes. 
II) Specificity of precise genome editing systems.
III) Evolutionary trajectory of CRISPR systems.

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Yuanyuan Jiang

Postdoc

Email: jiangyyuan(at)mail.tsinghua.edu.cn

Research Topic:

(1) Exploring the mechanisms and biological functions of ribozymes;

(2) Developing novel RNA-based nucleic acid manipulation tools within animal and plant organisms.

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Zheng Zhang

Postdoc

Email: zhengzhang61(at)mail.tsinghua.edu.cn

Research Topic:

Developing and optimizing RNA-based nucleic acid editing tools.
Editing is not manipulation but only guidance for the genome to fix itself.

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Danyuan Li

Ph. D. Candidate

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

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Jingbo Jiang

Ph. D. Candidate - joint PhD. student

Email: jiangjb18(at)mails.tsinghua.edu.cn

Research Topic:

(1)    Studying on physiological RNA substrate of RNA exosome complex in direct-access route by biochemistry and structure;
(2)    Exploring new cofactors of RNA exosome complex in yeast and human cells and determining the complex structures.

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Yun Yang​

Ph. D. Candidate

Email: yangyun19(at)mails.tsinghua.edu.cn

Research Topic:

My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.

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Mingzhe Xia

Ph. D. Candidate- joint PhD. student

Email: xmz19(at)mails.tsinghua.edu.cn

Research Topic:

(1) Study the mechanism of low phosphorus response and root hair development of Arabidopsis.
(2) Exploring the biochemical properties of plant transposase and their effects on biological functions.

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Chengping Li

Ph. D. Candidate

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.

Determining the 3D structures of proteins and RNAs using Cryo-EM.

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​Hanzhou Zhu

Ph. D. Candidate

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism. 
II) Developing a new method for RNA purification from in vivo system. 
III) RNA degradation by the exosome.

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Ao Sun

Ph. D. Candidate

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

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Shunqing Tan

Ph. D. Candidate

Email: tansq21(at)mails.tsinghua.edu.cn

Research Topic:

Exploring the mechanism of nuclease activities and developing novel gene editing tools.

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Zixian Liu

Ph. D. Candidate

Email: liuzx21(at)mails.tsinghua.edu.cn

Research Topic:

My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.

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Longqi Li

Ph. D. Student

Email: lilq22(at)mails.tsinghua.edu.cn

Research Topic:

Detection of gene-editing potential of novel nucleases in mammalian cells and Development of the next-generation gene-manipulating toolbox.

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Shuo Lin

Ph. D. Student

Email:lins23@mails.tsinghua.edu.cn

Research Topic:

Mining new ribozyme in matagenomic database and using structual biology approach to solve the mechenism

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Gaoli Wang

Ph. D. Student

Email: wanggl23(at)mails.tsinghua.edu.cn

Research Topic:

Searching for ribozymes with novel functions and exploring their applications as biological tools

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Shulin Jin

Ph. D. Student

Email: jsl23(at)mails.tsinghua.edu.cn

Research Topic:

Exploring the mechanism of novel RNA-involved nuclease system by using biochemistry methods.

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Zhonghao Zhang

Research assitant

Email: zhonghaozhang2022(at)163.com

I graduated from Ocean University of China with a master's degree. I am currently working as a research assistant. I am easy-going, sincere, ready to help others, serious and responsible for work.

Postdocs and Ph.D. Candidates...

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Alumni

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Dandan Sun

2020.4-2021.7, Lab Manager

​Current, Laboratory engineer​

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Xinyi Wu

2020.10-2021.4, Visiting Student

​Current, JiMei University​

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Zhuoyan Hai

2020.10-2021.8, Visiting Student

​Current, Ph.D. in Tsinghua University​

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Jiahui Zhao

2020.10-2021.8, Visiting Scholar 

​Current, master student 

                 in Columbia University​

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2021.5-2021.11, Visiting Scholar

Tingxuan Yang

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Yuqian Zhao

2020.5-2022.6, Postdoc

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Zhihao Jing

2021.9-2022.7, Visiting Scholar

Current, Tibet Agricultural and Animal Husbandry University

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Qiaoyang Ma

2021.9-2022.8, Visiting Student

Current, Ph.D. in Tsinghua University​

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Yutao Chen

2021.10-2022.7, Visiting Student

Current, Ph.D. in Tsinghua University​

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SweeHong Ng

2023.9-2024.4, Visiting Student

Current, in Tsinghua University​

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Min Li

​Lab Manager

Email: mmli(at)mail.tsinghua.edu.cn

Undergraduate Students

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Zhaofu Li

Tsinghua University

Grade 2021

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Qiyu Yang

Tsinghua University

Grade 2021

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 Yun Liu

Tsinghua University​

Grade 2021

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Xiaozheng Yang

Tsinghua University

Grade 2020

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Tsinghua University

Grade 2023

Runheng Zhang

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Matylda Zuzanna Klos 

University of Manchester

Grade 2021

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Jiantao Zhang

Tsinghua University

Grade 2023

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Yue Zhang

​Nanjing Agricultural University

Grade 2020

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Yuntian Yang

Lanzhou University

Grade 2020

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Wenwen Wang

Sun Yat-sen University

Grade 2019

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Yang Yi

Sichuan University

Grade 2020

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