Jun-Jie (Gogo) Liu
PI
Assistant professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University
​
junjiegogoliu(at)tsinghua.edu.cn
Please replace (at) with @ for contact
Current Members
Pujuan Deng
Postdoc
Email: dengpj(at)mail.tsinghua.edu.cn
Research Topic:
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
Shouyue Zhang
​Postdoc
Email: shouyuezhang(at)mail.tsinghua.edu.cn
Research Topic:
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
![mmexport1605609323137[1].jpg](https://static.wixstatic.com/media/105bd6_7cb6021337b847e7ab5fe2128ef44d36~mv2.jpg/v1/fill/w_240,h_320,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609323137%5B1%5D.jpg)
Danyuan Li
Ph. D. Candidate
Email: li-dy18(at)mails.tsinghua.edu.cn
Research Topic:
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
Yun Yang​
Ph. D. Candidate
Email: yangyun19(at)mails.tsinghua.edu.cn
Research Topic:
My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.
​Hanzhou Zhu
Ph. D. Candidate
Email: zhz20(at)mails.tsinghua.edu.cn
Research Topic:
I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.
Chengping Li
Ph. D. Candidate
Email: lcp20(at)mails.tsinghua.edu.cn
Research Topic:
Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.
Determining the 3D structures of proteins and RNAs using Cryo-EM.
Ao Sun
Ph. D. Candidate
Email: sunao20(at)mails.tsinghua.edu.cn
Research Topic:
1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools
![mmexport1605609348461[1].jpg](https://static.wixstatic.com/media/105bd6_07221a6d898548b6911c5e7fe70fc4b5~mv2.jpg/v1/crop/x_0,y_68,w_668,h_833/fill/w_247,h_308,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609348461%5B1%5D.jpg)
Zixian Liu
Ph. D. Student
Email: liuzx21(at)mails.tsinghua.edu.cn
Research Topic:
My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.
Shunqing Tan
Ph. D. Student
Email: tansq21(at)mails.tsinghua.edu.cn
Research Topic:
Exploring the mechanism of nuclease activities and developing novel gene editing tools.
Longqi Li
Ph. D. Student
Email: lilq22(at)mails.tsinghua.edu.cn
Research Topic:
Detection of gene-editing potential of novel nucleases in mammalian cells and Development of the next-generation gene-manipulating toolbox.
Postdocs and Ph.D. Candidates...
Alumni
Dandan Sun
2020.4-2021.7, Lab Manager
​Current, Laboratory engineer​
![mmexport1605609293265[1].jpg](https://static.wixstatic.com/media/105bd6_4e6a71bbf7c94e56928c53a67238aacf~mv2.jpg/v1/fill/w_113,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609293265%5B1%5D.jpg)
Xinyi Wu
2020.10-2021.4, Visiting Student
​Current, JiMei University​
![mmexport1605609264211[1].jpg](https://static.wixstatic.com/media/105bd6_6d67cfb2c1764cac8baba787c8ed61fd~mv2.jpg/v1/crop/x_415,y_357,w_451,h_544/fill/w_124,h_150,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/mmexport1605609264211%5B1%5D.jpg)
Zhuoyan Hai
2020.10-2021.8, Visiting Student
​Current, Ph.D. in Tsinghua University​
Jiahui Zhao
2020.10-2021.8, Visiting Scholar
​Current, master student
in Columbia University​
2021.5-2021.11, Visiting Scholar
​
Tingxuan Yang
Yuqian Zhao
2020.5-2022.6, Postdoc
​​
Zhihao Jing
2021.9-2022.7, Visiting Scholar
Current, Tibet Agricultural and Animal Husbandry University
​​
Qiaoyang Ma
2021.9-2022.8, Visiting Student
Current, Ph.D. in Tsinghua University​
​​
Yutao Chen
2021.10-2022.7, Visiting Student
Current, Ph.D. in Tsinghua University​
​​
Min Li
​Lab Manager
Email: mmli(at)mail.tsinghua.edu.cn
Zhihang Chen
Postdoc
Email: zhihangchen(at)mail.tsinghua.edu.cn
Research Topic:
Directed evolution of novel nucleic acid manipulation systems for precise & high efficiency gene editing.
