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Published Work


31. Zhang S#, Sun A#, Qian JM#, Lin S#, Xing WJ, Yang Y, Zhu HZ, Zhou XY, Guo YS, Liu Y, Meng Y, Jin SL, Song WH, Li CP, Li ZF, Jin S, Wang JH, Dong MQ, Gao C, Chen CL*, Bai Y*,  Liu JJ*. Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature (2024). 

30. Liu ZX#, Zhang S#, Zhu HZ#, Chen ZH#, Yang Y#, Li LQ#, Lei Y, Liu Y, Li DY, Sun A, Li CP, Tan SQ, Wang GL, Shen JY, Jin S, Gao C, Liu JJ*. Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage. Science, 383(6682): eadh4859(2024). 


29. Deng P#, Tan SQ#, Yang QY, Fu L, Wu Y, Zhu HZ, Sun L, Bao Z, Lin Y, Zhang QC, Wang HY, Wang J*, Liu JJ*. Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell (2023).

28. Hu Z#, Sun A#, Yang J, Naz Gul, Sun G, Li Z, Liu JJ*, Zhang S*, Zhang X*. Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA. Chem Sci (2023).

27. Li DY#, Li LQ#, Liu JJ*. Nucleases in gene-editing technologies: past and prologue. NSO (2023).

26. Sun A#, Li CP#, Chen Z#, Zhang S#, Li DY, Yang Y, Li LQ, Zhao Y, Wang K, Li Z, Liu J, Liu S, Wang J*, Liu JJ*. The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation. Cell Res (2023).


25. Tsuchida CA#, Zhang SY#, Doost MS#, Zhao YQ#, Wang J, O’Brien E, Fang H, Li CP, Li DY, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA*, Liu JJ*. Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. Mol Cell (2022).


24. Li S, Yan R, Xu JL, Zhao SQ, Ma XY, Sun QM, Zhang M, Li Y, Liu JJ, Chen LY, Li S, Xu K, Ge L*. A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis. Cell Res (2021). 

23. Yang MY, Sun RR, Deng PJ, Yang YZ, Wang WJ, Liu JJ*, Chen CL*. Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search. Chem. Sci (2021). (Co-responding Author)


22. Liu JJ*, Wang HW*. (2020) Cryo-Electron Microscopy of Endogenous Yeast Exosomes. Methods Mol. Biol., 2062:401-415. (Book Chapter)


21. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.  Elife. 2019 Aug 9;8. pii: e49110. 

20. Liu TY#, Liu JJ#Aditham AJ, Nogales E, Doudna JA. Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble. Nature Communications,10(1),3001(2019).  (Co-first Author)

19.Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knot GJ, Harrington L, Al-Shayeb B, Wanger A, Brotzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA. CasX enzymes comprise a distinct family of RNA-guided genome editors.Nature, 566,218-223 (2019).  


18. Knott GJ, Thornton BW, Lobba MJ, Liu JJ, Al-Shayeb B, Watters KE, Doudna JA. Broad-spectrum enzymatic inhibition of CRISPR-Cas12a. Nature structural & molecular biology. 2019 Apr;26(4):315-21.


17. Jiang F#, Liu JJ#, Osuna BA#, Xu M, Berry JD, Rauch BJ, Nogales E, Denomy JB, Doudna JA. Temperature-responsive competitive inhibition of CRISPR-Cas9. Mol Cell, 1016-016(2018). (Co-first Author)


16. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell, 170, 1224-1233 (2017).

15. Wright AV#, Liu JJ#, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Structures of the CRISPR genome integration complex. Science, 357, 1113-1118 (2017). (Co-first Author)

14. Shing J#, Jiang F#, Liu JJ#, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances, 3(7): e1701620(2017). (Co-first Author)

13. Ma M#, Liu JJ#, Li Y, Huang Y, Ta N, Chen Y, Fu H, Ye MD, Ding Y, Huang W, Wang J,Dong MQ, Yu L, Wang HW. Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2. Cell Research, 27,989-1001(2017). (Co-first Author)


12.Liu JJ, Niu CY, Wu Y, Tan D, Wang Y, Ye MD, Dong MQ, Huang N & Wang HW, CryoEM structure of yeast cytoplasmic exosome complex. Cell Research, 26, 822-837(2016).

11. Gong X, Qian H, Shao W, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N, Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research,26,1197-1211(2016).

10. Tan D, Li Q, Zhang MJ, Liu C, Ma C, Zhang P, Ding YH, Fan SB, Tao L, Yang B, Li X, Ma S, Liu JJ, Feng B, Liu X, Wang HW, He SM, Gao N, Ye K, Dong MQ, Lei XTrifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational statesElife, pii, e12509 (2016).

2015 and Before

9. Liu JJ,Bratkowski MA, Liu XQ, Niu CY, Ke AL & Wang HW, Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM. Nature Structural & Molecular Biology, 21, 95–102 (2014).

8. Yin P, Li QX, Yan CY,Liu Y,Liu JJ, Yu F, Wang Z, Long JF, He JH, Wang HW, Wang JW, Zhu JK, Shi YG & Yan N, Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504, 168–171 (2013).

7. Liu JJ, Lin M, Yu JY, Liu B, Bao JK. Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Letters, 300(2):105-114 (2011).

6. Li CY, Luo P, Liu JJ, Wang EQ, Li WW, Ding ZH, Mou L, Bao JK. Recombinant expression of Polygonatum cyrtonema lectin with anti-viral, apoptosis-inducing activities and preliminary crystallization. Process Biochemistry, 46(2): 533-542 (2011).

5. Zhang F, Li CY, Wang EQ, Li WW, Yu QJ, Wen X, Liu JJ, Bao JK. The global component-target network in Panax Ginseng C. Letters in Drug Design & Discovery, 8, 181-188 (2011).

4. Yang Y, Xu HL, Zhang ZT, Liu JJ, Li WW, Ming H, Bao JK. Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities. Phytomedicine,18(8-9):748-755 (2011).

3. Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. Biochimie, 92(12):1934-1938 (2010).

2. Yao Q, Wu CF, Luo P, Xiang XC, Liu JJ, Mou L, Bao JK. A new chitin-binding lectin from rhizome of Setcreasea purpurea with antifungal, antiviral and apoptosis-inducing activities. Process Biochemistry, 45(9): 1477-1485 (2010).

1. Zhang ZT, Peng H, Li CY, Liu JJ, Zhou TT, Yan YF, Li Y, Bao JK. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine, 18(1):25-31 (2010).

# Co-first Author, * Corressponding Author

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